Synthesis of New Trisubstituted 4‐Aminopiperidines as PAF‐Receptor Antagonists
Identifieur interne : 000541 ( Main/Exploration ); précédent : 000540; suivant : 000542Synthesis of New Trisubstituted 4‐Aminopiperidines as PAF‐Receptor Antagonists
Auteurs : Houcine Benmehdi [Algérie] ; Aazdine Lamouri ; Nawal Serradji ; Frédérique Pallois ; Françoise Heymans [France]Source :
- European Journal of Organic Chemistry [ 1434-193X ] ; 2008-01.
English descriptors
Abstract
Two novel classes of 4‐aminopiperidines substituted in the 3‐position by groups bearing either a carbamate or a ureido function have been synthesized from ethyl 4‐oxo‐3‐piperidinecarboxylate and 3,3′‐iminobis(propanenitrile), respectively. The key step in this synthesis, the reduction of the piperidinic β‐enamino ester or nitrile, occurred readily. In contrast to published works, the free primary amines could be isolated from the corresponding β‐amino ester or nitrile. Regioselective amidification of the amino group offered two pairs of diastereoisomers which were successfully separated and identified. Measurement of PAF‐receptor antagonist activity gave interesting results with an IC50 close to the micromolar.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
Url:
DOI: 10.1002/ejoc.200700667
Affiliations:
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The key step in this synthesis, the reduction of the piperidinic β‐enamino ester or nitrile, occurred readily. In contrast to published works, the free primary amines could be isolated from the corresponding β‐amino ester or nitrile. Regioselective amidification of the amino group offered two pairs of diastereoisomers which were successfully separated and identified. Measurement of PAF‐receptor antagonist activity gave interesting results with an IC50 close to the micromolar.(© Wiley‐VCH Verlag GmbH & Co. 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